MOSCI , Carlo

Last name: MOSCI

First name: Carlo

2018 (v1)

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Prognostic value of chromosomal imbalances, gene mutations, and BAP1 expression in uveal melanoma

PATRONE, SERENA Maric, Irena RUTIGLIANI, MARIANGELA

Uveal melanoma (UM) exhibits recurring chromosomal abnormalities and gene driver mutations, which are related to tumor evolution/progression. Almost half of the patients with UM develop distant metastases, predominantly to the liver, and so far there are no effective adjuvant therapies. An accurate UM genetic profile could assess the individual...

Uploaded on: April 14, 2023
2022 (v1)

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In uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations

Piaggio, Francesca Croce, Michela Reggiani, Francesco

Background and aim of the study: Mutations in the G alpha-genes GNAQ and GNA11 are found in 85-90% of uveal melanomas (UM). Aim of the study is to understand whether the mutations in both genes differentially affect tumor characteristics and outcome and if so, to identify potential mechanisms.Methods: We analyzed the association between GNAQ...

Uploaded on: February 14, 2024
2016 (v1)

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Analysis of the Expression and Single-Nucleotide Variant Frequencies of the Butyrophilin-like 2 Gene in Patients With Uveal Melanoma

AMARO, ADRIANA AGNESE Parodi, Federica Diedrich, Konrad

IMPORTANCE Chromosome 6p amplification is associated with more benign behavior for uveal melanomas (UMs) with an otherwise high risk of metastasis conferred by chromosome 3 monosomy. Chromosome 6p contains several members of the B7 family of immune regulator genes, including butyrophilin-like 2 (BTNL2; OMIM, 606000), which is associated with...

Uploaded on: April 14, 2023

MOSCI , Carlo

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