MOTILVA SÁNCHEZ , Virginia

La úlcera péptica es un conjunto de factores heterogéneos que se manifiestan como una disfunción de la capa mucosa gastrointestinal bañada por ácido y pepsina. En algunas úlceras, la agresión por pepsina-ácido es de importancia capital, en otras existe una carencia o defecto de las defensas de la mucosa. El tratamiento farmacológico de la...

The objective of the present study has been to advance knowledge of the gastric role played by the amino acid L-Arginine (L-Arg) in the evolution of a chronic gastric ulcer. In order to clarify it, L-Arg alone or together with Ibuprofen have been administrated in an experimental acetic acid chronic ulcer, analysing characteristic parameters of...

Colorectal cancer (CRC) is one of the most common types of cancers and a leading cause of cancer death worldwide. The current treatment for CRC mainly involves surgery, radiotherapy, and chemotherapy. However, due to the side effects and the emergence of drug resistance, the search for new anticancer agents, pharmacologically safe and...

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Adrenomedullin (AM) is a 52 amino acid peptide that has shown predominant anti-inflammatory activities. In the present study, we evaluated the possible therapeutic effect of this peptide in an experimental model of acute inflammation, the carrageenan-(CAR-) induced pleurisy. Pleurisy was induced by injection of CAR into the pleural cavity of...

This study was aimed to know the immunomodulatory effects of defined extra virgin olive oil (EVOO) diets on indomethacin induced gastric lesion. Methods: Different groups were fed with diets: standard diet (5 g of fat/100 g of diet), and EVOO-5 and EVOO-20 (5 or 20 g/100 g of diet, respectively). After 6 weeks, each dietary group was divided...

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Excessive exposure to ultraviolet (UV) radiation is the main risk factor to develop skin pathologies or cancer because it encourages oxidative condition and skin inflammation. In this sense, strategies for its prevention are currently being evaluated. Natural products such as carotenoids or polyphenols, which are abundant in the marine...

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Acute inflammation is a key component of the immune system's response to pathogens, toxic agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing pathogenic factors and restoring tissue homeostasis. However, uncontrolled acute inflammatory response may lead to chronic inflammation, which is involved in the...

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