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MOUILLAC , Bernard

Last name: MOUILLAC

First name: Bernard

January 12, 2024 (v1)

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Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification

Recio Jiménez, Rocío Vengut-Climent, Empar Mouillac, Bernard

A library of 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyrans has been synthesized as a new family of non-peptide NK1 receptor ligands by a one-pot cascade process. Their biological effects via interaction with the NK1 receptor were experimentally determined as percentage of inhibition (for antagonists) and percentage of activation...

Uploaded on: January 14, 2024
November 26, 2021 (v1)

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Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity

Recio Jiménez, Rocío Lerena Pérez, Patricia Pozo Torres, Esther

NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment of several cancers. In the present study, we report on the synthesis of carbohydrate-based NK1R antagonists and their evaluation as anticancer agents against a wide range of cancer cells. All of the prepared compounds,...

Uploaded on: March 25, 2023