MUÑOZ BARRERA , Marta

Para garantizar una correcta segregación cromosómica, no sólo es importante asegurarse de que todos los cinetocorosde los cromosomasestén unidosal huso por medio de microtúbulos, sino que también es esencial que lo hagan de forma que ambas cromátidashermanasde cada par se encuentrenunidasa un polo diferente del huso mitótico. Esto es lo que se...

Aurora B kinase regulates the proper biorientation of sister chromatids during mitosis. Lack of Aurora B kinase function results in the inability to correct erroneous kinetochore-microtubule attachments and gives rise to aneuploidy. Interestingly, increased Aurora B activity also leads to problems with chromosome segregation, and overexpression...

Aurora B and the spindle assembly checkpoint (SAC) collaborate to ensure the proper biorientation of chromosomes during mitosis. However, lack of Aurora B activity and inactivation of the SAC have a very different impact on chromosome segregation. This is most evident in Saccharomyces cerevisiae, since in this organism the lack of Aurora B is...