N

L

NAESENS , Lieve

Last name: NAESENS

First name: Lieve

2017 (v1)

Publication

Metadata-only

Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus

TONELLI, MICHELE Naesens, Lieve Gazzarrini, Sabrina

We have identified a series of 1-aryl-4,6-diamino-1,2-dihydrotriazines, structurally related to the antimalarial drug cycloguanil, as new inhibitors of influenza A and B virus and respiratory syncytial virus (RSV) via targeting of the host dihydrofolate reductase (DHFR) enzyme. Most analogues proved active against influenza B virus in the low...

Uploaded on: April 14, 2023