NAPOLITANO , Antonella

Introduction: Is the replacement of ethinyl-estradiol (EE) with estradiol (E2) in combined hormonal contraceptives (CHCs) associated with fewer metabolic effects, leading to a further improvement on safety of hormonal contraceptives? Areas covered: This is a narrative review paper including all available data on the metabolic impact of CHCs...

Objective To evaluate whether climacteric symptoms are related to pelvic organ prolapse (POP) in postmenopausal women. Study design A cross-sectional investigation was performed on 1382 postmenopausal women attending an outpatient service for menopause at a university hospital. Main outcome measures Data regarding climacteric symptoms, as...

The progestin dienogest (DNG) given alone effectively reduces pelvic pain of women with endometriosis. It is not clear whether the same occurs when DNG is associated with estradiol (E2).

Objective: To study the three cycles effect on primary dysmenorrhea of the monophasic 24/4 estradiol/nomegestrol acetate (E2/NOMAC) and of the 21/7 ethinyl-estradiol/chlormadinone acetate (EE/CMA) oral contraceptive. The tolerability and the effect of both preparations on metabolism and health-related quality of life were also...

Objective The effect on body composition and in particular on fat mass (FM) of 12 months ' use of a desogestrel (DSG)-only contraceptive pill or the levonorgestrel-releasing intrauterine system (LNG-IUS) was evaluated in women in the perimenopause. Methods An observational study comprised 102 perimenopausal women: 42 received a 75 μ g DSG pill,...