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NETTI , Vanina

Last name: NETTI

First name: Vanina

December 29, 2023 (v1)

Publication

Metadata-only

Aquaporin-4 removal from the plasma membrane of human muller cells by AQP4-IgG from patients with neuromyelitis optica induces changes in cell volume homeostasis: the first step of retinal injury?

Netti, Vanina Fernández, Juan Melamud, Luciana

Aquaporin-4 (AQP4) is the target of the specifc immunoglobulin G autoantibody (AQP4-IgG) produced in patients with neuromyelitis optica spectrum disorders (NMOSD). Previous studies demonstrated that AQP4-IgG binding to astrocytic AQP4 leads to cell-destructive lesions. However, the early physiopathological events in Müller cells in the retina...

Uploaded on: December 31, 2023