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NIKPOOR , Amin Reza

Last name: NIKPOOR

First name: Amin Reza

2017 (v1)

Publication

Metadata-only

IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells

Carbotti, Grazia Nikpoor, Amin Reza Vacca, Paola

Background: Recently, immunotherapy with anti-PD-1 antibodies has shown clinical benefit in recurrent Small Cell Lung Cancer (SCLC). Since anti-PD-1 re-activates anti-tumor Cytotoxic T Lymphocyte (CTL) responses, it is crucial to understand the mechanisms regulating HLA class I, and PD-L1 expression in HLA-negative SCLC. Here we addressed the...

Uploaded on: August 22, 2024