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February 2017 (v1)Journal articleUploaded on: December 4, 2022
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July 28, 2017 (v1)Journal article
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Uploaded on: December 4, 2022 -
2021 (v1)Journal article
Fibrosis is a deleterious invasion of tissues associated with many pathological conditions, such as Duchenne muscular dystrophy (DMD) for which no cure is at present available for its prevention or its treatment. Fibro-adipogenic progenitors (FAPs) are resident cells in the human skeletal muscle and can differentiate into myofibroblasts, which...
Uploaded on: December 4, 2022 -
2018 (v1)Journal article
Root-knot nematodes, Meloidogyne spp., are obligate endoparasites that maintain a biotrophic relationship with their hosts. They infect roots as microscopic vermiform second-stage juveniles, and establish specialized feeding structures called 'giant-cells', from which they withdraw water and nutrients. The nematode effector proteins secreted in...
Uploaded on: December 4, 2022 -
March 28, 2018 (v1)Journal article
In BRAFV600E melanoma cells, a global metabolomic analysis discloses a decrease in nicotinamide adenine dinucleotide (NAD+) levels upon PLX4032 treatment that is conveyed by a STAT5 inhibition and a transcriptional regulation of the nicotinamide phosphoribosyltransferase (NAMPT) gene. NAMPT inhibition decreases melanoma cell proliferation both...
Uploaded on: December 4, 2022 -
April 2018 (v1)Journal article
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Uploaded on: December 4, 2022 -
November 2018 (v1)Journal article
HACE1 is an E3 ubiquitin ligase described as a tumour suppressor because HACE1-knockout mice develop multi-organ, late-onset cancers and because HACE1 expression is lost in several neoplasms, such as Wilms' tumours and colorectal cancer. However, a search of public databases indicated that HACE1 expression is maintained in melanomas. We...
Uploaded on: December 4, 2022 -
April 20, 2018 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
2013 (v1)Journal article
Root-knot nematodes are globally the most aggressive and damaging plant-parasitic nematodes. Chemical nematicides have so far constituted the most efficient control measures against these agricultural pests. Because of their toxicity for the environment and danger for human health, these nematicides have now been banned from use. Consequently,...
Uploaded on: March 25, 2023 -
April 20, 2018 (v1)Journal article
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Uploaded on: February 22, 2023 -
August 22, 2017 (v1)Journal article
Extracellular vesicles (EVs) have been shown to play an important role in intercellular communication as carriers of DNA, RNA and proteins. While the intercellular transfer of miRNA through EVs has been extensively studied, the stability of extracellular miRNA (ex-miRNA) once engulfed by a recipient cell remains to be determined. Here, we...
Uploaded on: December 4, 2022 -
November 14, 2019 (v1)Journal article
Lung cancer is the leading cause of cancer death worldwide, with poor prognosis and a high rate of recurrence despite early surgical removal. Hypoxic regions within tumors represent sources of aggressiveness and resistance to therapy. Although long non-coding RNAs (lncRNAs) are increasingly recognized as major gene expression regulators, their...
Uploaded on: February 22, 2023 -
November 2019 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
November 14, 2019 (v1)Journal article
Lung cancer is the leading cause of cancer death worldwide, with poor prognosis and a high rate of recurrence despite early surgical removal. Hypoxic regions within tumors represent sources of aggressiveness and resistance to therapy. Although long non-coding RNAs (lncRNAs) are increasingly recognized as major gene expression regulators, their...
Uploaded on: December 4, 2022 -
January 2021 (v1)Journal article
Resistances to immunotherapies remains a major hurdle towards a cure for melanoma in numerous patients. An increase in the mesenchymal phenotype and a loss of differentiation have been clearly associated with resistance to targeted therapies. Similar phenotypes have been more recently also linked to resistance to immune checkpoint therapies. We...
Uploaded on: December 4, 2022 -
July 8, 2022 (v1)Journal article
Depletion of circulating asparagine with l -asparaginase (ASNase) is a mainstay of leukemia treatment and is under investigation in many cancers. Expression levels of asparagine synthetase (ASNS), which catalyzes asparagine synthesis, were considered predictive of cancer cell sensitivity to ASNase treatment, a notion recently challenged. Using...
Uploaded on: December 3, 2022 -
December 2020 (v1)Journal article
Ubiquitination by serving as a major degradation signal of proteins, but also by controlling protein functioning and localization, plays critical roles in most key cellular processes. Here, we show that MITF, the master transcription factor in melanocytes, controls ubiquitination in melanoma cells. We identified FBXO32, a component of the SCF...
Uploaded on: December 4, 2022 -
July 2019 (v1)Journal article
The respiratory epithelium arises from alveolar epithelial progenitors which differentiate into alveolar epithelial type 1 (AT1) and type 2 (AT2) cells. AT2 cells are stem cells in the lung critical for the repair process after injury. Mechanisms regulating AT1 and AT2 cell maturation are poorly defined. We report that the activation of the...
Uploaded on: December 4, 2022 -
July 2019 (v1)Journal article
International audience
Uploaded on: February 22, 2023 -
2019 (v1)Journal article
Phenotypic plasticity and subsequent generation of intratumoral heterogeneity underly key traits in malignant melanoma such as drug resistance and metastasis. Melanoma plasticity promotes a switch between proliferative and invasive phenotypes characterized by different transcriptional programs of which MITF is a critical regulator. Here, we...
Uploaded on: December 4, 2022 -
July 2019 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
October 19, 2020 (v1)Journal article
Mammary carcinoma, including triple-negative breast carcinomas (TNBC) are tumor-types for which human and canine pathologies are closely related at the molecular level. The efficacy of an oncolytic vaccinia virus (VV) was compared in low-passage primary carcinoma cells from TNBC versus non-TNBC. Non-TNBC cells were 28 fold more sensitive to VV...
Uploaded on: December 4, 2022