ORIENTI , Isabella

All-trans-retinoic acid (ATRA) is being increasingly included in antitumor therapeutical schemes for the treatment of various type of tumors; however the difficulty of increasing plasma concentrations of ATRA in vivo hindered, until now, a correct evaluation of its possible pro-apoptotic effect towards both the proliferating and non...

This study relates to the preparation of a series of amphiphilic dextrins and their evaluation as complexing agents for anti-tumor hydrophobic drugs such as fenretinide, paclitaxel, etoposide, and camptothecin. The amphiphilic dextrins were obtained by conjugation of low molecular weight dextrin (average molecular weight 1670, average...