O

J

OEHLER , Judith

Last name: OEHLER

First name: Judith

March 20, 2019 (v1)

Publication

Metadata-only

The ubiquitin E3/E4 ligase, UBE4A, fine-tunes protein ubiquitylation and accumulation at sites of DNA damage facilitating double-strand break repair

Soria Bretones, Isabel Baranes Bachar, Keren Huertas Sánchez, Pablo

Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning - the E3/E4 ubiquitin ligase, UBE4A. UBE4A's recruitment to sites of DNA damage is dependent on primary E3 ligases in the DDR and promotes enhancement and sustainment of...

Uploaded on: March 27, 2023