ORTHOLAN , Cécile

MicroRNAs (miRNAs) are small non-protein-coding RNA that negatively control mRNA expression at a post-transcriptional level. They regulate various cellular functions and bioinformatic data suggest that they collectively control about 30% of human mRNAs. MiRNAs have been recently implicated in several carcinogenic processes, where they can act...

Monte Carlo (MC) simulation in radiotherapy is well known to be the reference forpatient deposit dose estimation. Correlation between CT images and MC tissue parameters isa major step before the estimation of the deposit dose. It requires transforming the CT dicomimages in the geometry input of MC code, and depends on the chosen samplings,...

Bevacizumab (Bvz), a Vascular Endothelial Growth Factor (VEGF)-targeted humanised monoclonal antibody, provides clinical benefit in combination with docetaxel (DXL), a microtubule-stabilising agent, in the treatment of metastatic breast and prostate cancers. Since VEGF and their receptors are expressed by tumour cells, we hypothesised that Bvz,...

The pattern of protein expression in tumours is under the influence of nutrient stress, hypoxia and low pH, which determines the survival of neoplastic cells and the development of tumours. Carbonic anhydrase XII (CAXII) is a transmembrane enzyme which catalyzes the reversible hydration of cell-generated carbon dioxide into protons and...