O

F

ORTUSO , Francesco

Last name: ORTUSO

First name: Francesco

2016 (v1)

Publication

Metadata-only

SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells

Talarico, Cristina Dattilo, Vincenzo D'Antona, Lucia

Glioblastoma multiforme (GBM) is the most aggressive CNS tumor and is characterized by a very high frequency of clinical relapse after therapy and thus by a dismal prognosis, which strongly compromises patients survival. We have recently identified the small molecule SI113, as a potent and selective inhibitor of SGK1, a serine/threonine protein...

Uploaded on: April 14, 2023