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PÉCOU , Elisabeth

Last name: PÉCOU

First name: Elisabeth

June 9, 2009 (v1)

Journal article

Metadata-only

Gene regulation in response to graded hypoxia: The non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway

Dayan, Frédéric Monticelli, Marc Pouysségur, Jacques

Hif, being the master protein involved in adaptation to low p[O], plays a major role in many physiological and pathological phenomena: development, inflammation, ischemia and cancer. PHD and FIH are the two oxygen sensors that regulate the Hif pathway. Here we model the regulatory dynamics in an oxygen gradient by a system of differential...

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