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PÉREZ RENTERO , Sonia

Last name: PÉREZ RENTERO

First name: Sonia

August 13, 2018 (v1)

Publication

Metadata-only

Glucose conjugation of anti-HIV-1 oligonucleotides containing unmethylated CpG motifs reduces their immunostimulatory activity

Reyes Darias, J. A. Sánchez Luque, Francisco J. Morales, Juan C.

Antisense oligodeoxynucleotides (ODNs) are short synthetic DNA polymers complementary to a target RNA sequence. They are commonly designed to halt a biological event, such as translation or splicing. ODNs are potentially useful therapeutic agents for the treatment of different human diseases. Carbohydrate-ODN conjugates have been reported to...

Uploaded on: March 27, 2023
July 13, 2022 (v1)

Publication

Metadata-only

Synthesis, cell-surface binding, and cellular uptake of fluorescently labeled glucose-DNA conjugates with different carbohydrate presentation

Ugarte Uribe, Begoña Pérez Rentero, Sonia Lucas Rodríguez, Ricardo

Oligonucleotide conjugates carrying carbohydrates at the 5′-end have been prepared. Glucose, fucose, and saccharides containing glucose at the nonreducing end were attached to DNA strands using the classical phosphoramidite chemistry. Two types of spacers and a dendron scaffold helped to obtain a diversity of sugar presentations in the DNA...

Uploaded on: December 4, 2022