PALMIERI , Daniela

Lack of estrogen is a cause of cardiovascular disease in men and postmenopausal women. We examined the effects of estrogen receptors (ERs) activation/inactivation on endothelial cells subjected to tumor necrosis factor (TNF)α, which is involved in vascular disease pathogenesis. Endothelial nitric oxide synthase (eNOS) and matrix...

Apigenin is a naturally occurring plant flavone with strong antioxidant and anti-inflammatory activity. While the anticancer properties of Apigenin have been extensively studied, little is known about its effects on endothelial dysfunction. We investigated the effects of Apigenin in EAhy926 endothelial cells exposed to TNFa by evaluating the...

Purpose: One of the limitations emerged with both synthetic and degradable vascular grafts is the lack of endothelialization after implantation that is known to be the main reason leading to unfavourable outcomes. It emerges the need to find new strategies to promote a rapid endothelialization of the scaffold. Pleiotrophin is a...

No description

No description

No description

No description

The antiradical power of the methanol extracts of olive pomace (Taggiasca cultivar) achieved by high pressure-high temperature reactor were investigated using ABTS•+ and DPPH• assays. The highest antioxidant activity was quantified at 90 min of contact time and 180 °C of extraction temperature (64.19±0.16 μgTE/L and 15.80±0.62...

Shortened telomere length (TL) and oxidative stress have been described in several vascular disorders at both the tissue and circulating level. However, to our knowledge, there are no reports about TL associated with varicose vein (VV) disease. This paper aimed to evaluate, at the tissue and circulating level, TL and oxidative stress in VV...

MicroRNAs have been proposed as novel regulators of vascular inflammation and dysfunction. This study aimed to evaluate the role of miR-149 in regulating the expression of key molecules associated with TNFα-induced endothelial activation. miR-149 was selected by in silico analysis and microRNA target prediction. Endothelial dysfunction was...

The cyanobacterium Arthrospira platensis (A. platensis) has been considered as a potential source of several therapeutic compounds including antioxidant molecules such as phenolics. Several studies have demonstrated that the exposure to a particular stress factor, such as UV-light, is able to modify the quality and the quantity of polyphenols...

No description

No description

This study proposes an alternative technique to prevent heat degradation induced by classic procedures of bioactive compound extraction, comparing classical maceration/decoction in hot water of polyphenols from Mango (Mangifera indica L.) (MI) with ultrasound-assisted extraction (UAE) in a water solution of β-cyclodextrin (β-CD) at room...

BACKGROUND: The COOH terminal peptide of Pro-collagen type I (PICP, also called C3) is chemotactic for endothelial melanoma and breast cancer cells. PICP induces the expression of Metalloproteinases-2 and -9, of Vascular endothelial growth factor and of the chemokine CXCL-12 receptor CXCR4 in MDA MB231 breast carcinoma cells in vitro. METHODS:...

No description

Abdominal Aortic Aneurysm (AAA) is related to chronic mural inflammation in which activation of the Renin-Angiotensin system (RAS), infiltration of mononuclear phagocytes and other leukocytes contribute to proteolytic activity, aortic tissue damage and AAA expansion. Resveratrol is a natural antioxydant polyphenol with vasoprotective...

No description

Resveratrol (Rsv) is a natural antioxidant polyphenol with vasoprotective properties. We evaluated whether Rsv affects the inflammatory response in an experimental model of elastase-induced abdominal aortic aneurysm. Thirty male rats were subjected to aneurysm induction and treated or not with Rsv. Circulating levels of CD62L-monocyte subset,...

No description

The cell adhesion molecule CD146 is normally located at the endothelial cell-to-cell junction and colocalizes with actin cytoskeleton. The soluble form of CD146 (sCD146) has been identified in the endothelial cell supernatant and in normal human plasma, and is increased in pathologic conditions with altered endothelial function. Soluble CD146...

BACKGROUND: Monocyte activation, macrophage infiltration, vascular oxidative stress and matrix proteolysis are inflammatory key steps contributing to abdominal aortic aneurysm (AAA) development. A phenotypical and functional heterogeneity is recognizable in monocytes by the differential expression of surface molecules: CD62L- subset corresponds...

Anoxia modulates the expression of molecules associated with endothelial dysfunction and vascular diseases. Polyphenols have potent antioxidant properties due to their ability to modulate genes involved in oxidative tissue damage. In this study, we investigated the effect of polyphenol extract from olive pomace (PEOP) and its main...