2010 (v1)
Publication
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P
M
PEDRAZZI , Marco
Last name: PEDRAZZI
First name: Marco
Email: marco.pedrazzi@unige.it
Institution: UNIGE
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2009 (v1)Publication
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2010 (v1)Publication
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2012 (v1)Publication
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Uploaded on: May 13, 2023 -
2016 (v1)Publication
Matrix metalloproteinase 9 (MMP9) is physiologically involved in remodeling the extracellular matrix components but its abnormal release has been observed in several human pathologies, including cystic fibrosis. We have studied if the alteration in intracellular Ca2+homeostasis, observed in peripheral blood mononuclear cells (PBMCs), isolated...
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2000 (v1)Publication
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2000 (v1)Publication
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1999 (v1)Publication
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2009 (v1)Publication
We show that protein kinase C (PKC) h localized at the Golgi complex is partially conjugated to monoubiquitin. Using the inactive T538A and activable T538E mutants of PKCh, we demonstrate that the presence of an uncharged residue at the 538 position of the activation loop favors both association with the Golgi and monoubiquitination of the...
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2007 (v1)Publication
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2016 (v1)Publication
Although many reports indicate the involvement of calpain in several human pathologies, it is not yet clarified how the protease can recognize the substrates to digest and how can escape to its natural inhibitor calpastatin. Answers to these questions have been obtained by identifying specific intracellular localizations of calpain and its...
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2010 (v1)Publication
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2014 (v1)Publication
Elevation in [Ca2+]i and activation of calpain-1 occur in central nervous system of SOD1G93A transgenic mice model of amyotrophic lateral sclerosis (ALS), but few data are available about the early stage of ALS. We here investigated the level of activation of the Ca2+-dependent protease calpain-1 in spinal cord of SOD1G93A mice to ascertain a...
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2011 (v1)Publication
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2002 (v1)Publication
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2005 (v1)Publication
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2001 (v1)Publication
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2006 (v1)Publication
The multifunctional protein high mobility group box 1 (HMGB1) is expressed in hippocampus and cerebellum of adult mouse brain. Our aim was to determine whether HMGB1 affects glutamatergic transmission by monitoring neurotransmitter release from glial (gliosomes) and neuronal (synaptosomes) re-sealed subcellular particles isolated from...
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2014 (v1)Publication
Here we demonstrate that the presence of the L-domain in calpastatins induces biphasic interaction with calpain. Competition experiments revealed that the L-domain is involved in positioning the first inhibitory unit in close and correct proximity to the calpain active site cleft, both in the closed and in the open conformation. At high...
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2011 (v1)Publication
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Uploaded on: April 14, 2023