PINTO , Giulia

The challenge to defeat diseases starting from a rapid diagnosis has been relighted by the last pandemic due to SARS-CoV-2. The development of biosensors able to recognize molecular adsorption on surfaces plays a crucial role in this issue, allowing for example to detect the presence of disease biomarkers, like specific nucleic acid sequences...

We have studied the self-assembly of 22-base oligonucleotides bound by a short alkyl thiol linker (C 6 -ssDNA) on flat Au films. The self-assembled monolayer (SAM) was modified by addition of a spacer (mercaptohexanol, MCH). Molecular depositions were monitored in situ by spectroscopic ellipsometry (SE). SAMs were characterized in a liquid...