POCCI , Marco

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In order to make new tools available for investigating interactions between enzyme and substrate-like inhibitors in copper amine oxidases (CAOs), a class of enzymes that controls important cellular processes such as the crosslinking of elastin and collagen, cell proliferation and the regulation of intracellular polyamines, starting from a...

Through the synthesis and study of model systems as proper dithiane derivatives, vinyl monomers and soluble copolymeric reagents containing 2-unsubstituted 1,3-dithiane rings, we attained the key synthon 1,3-dithiane-5-methanol. Through its reaction with commercial resins, new polymeric reagents useful for supported organic synthesis and...

Gene therapy requires the delivering of genetic materials to the interior of a target cell through specific vectors which can be viral or nonviral. Nonviral synthetic vectors are considered a very promising, safer alternative to the viral ones which are used at present in the majority of clinics, but suffer from drawbacks such as immune...

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Saccharidic monomers and a macromonomer were synthesized and copolymerized in the presence of divinylbenzene (DVB) as crosslinker in conditions of separation of phases to give hydrophilic nanostructured sugar-based vinyl copolymers. Appropriate model molecules such as N-benzyl-D-gluconamide for the saccharidic copolymers and...

As a part of a work aimed at the synthesis of properly functionalized nanostructured glycopolymers suitable for interaction studies with copper amine oxidases, D-galactose was transformed through a six step sequence into monomer N-(4-vinylbenzoyl)-6-amino-6-deoxy-D-galactose (1) which was converted into nanostructured crosslinked polymers (R1)...

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The synthesis of polymer-supported 2-monosubstituted 1,3-dithianes from soluble copolymers bearing 1,3-propanedithiol groups, their lithiation, reactions with electrophiles such as aldehydes, ketones also alpha,beta-unsaturated and oxiranes, and cleavage of the produced dithioketal-protected alpha- or beta-hydroxyketones with various reagents...

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In order to obtain substrate-like inhibitors of copper amine oxidases (CAOs), a class of enzymes involved in important cellular processes as well as in crosslinking of elastin and collagen and removal of biogenic primary amines, we synthesized a set of benzylamine derivatives properly substituted at positions 2 and 6 and studied their...

The glycosylation of D-galactose glycopolymers to produce functionalized polymers expected to be bioactive as substrates or inhibitors of enzymes of the copper amine oxidase class (CAOs, EC 1.4.3.6), attained previously with an unpractical, but significant process requesting a large excess of glycosyl acceptor, has now been achieved with a...

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Sugar-based co-polymers with saccharidic units in stable cyclic form and nanometric morphologies stabilized through crosslinking, adaptable through specific functionalizations to biochemical interaction studies with copper-containing amine oxidases, were synthesized from appropriate monomers and macromonomers. The most promising nanospherical...