PRANDO R.

Red blood cell (RBC) concentrations of sorbitol and reduced glutathione (GSH) were evaluated in 29 type II diabetic subjects and eight normal controls. In erythrocytes from diabetic subjects, sorbitol levels were higher (18.7 ± 1.33 v 11.2 ± 0.7 nmol/g hemoglobin [Hb], P < .001) and GSH levels were lower (5.48 ± 0.19 v 8.33 ± 0.24 μmol/g Hb, P...

The main purpose of this work was to study the possible differences in insulin secretion in a large group of type 2 diabetic patients in relation to diabetes duration, obesity, and the presence of secondary failure after treatment with oral hypoglycemic agents. RESEARCH DESIGN AND METHODS - There were 147 nonobese and 215 obese type 2 diabetic...