P

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PABIS , M

Last name: PABIS

First name: M

January 28, 2019 (v1)

Publication

Metadata-only

HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

García Mauriño, Sofía M. Pabis, M Popowicz, GM

HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA recognition motifs (RRMs) where the structure and RNA binding of RRM3 and of full-length HuR remain poorly understood. Here, we report crystal structures of RRM3 free and...

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