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PACCAGNELLA , Matteo

Last name: PACCAGNELLA

First name: Matteo

2018 (v1)

Publication

Metadata-only

Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools

Liessi, Nara Cichero, Elena Pesce, Emanuela

The most common CF mutation, F508del, impairs the processing and gating of CFTR protein. This deletion results in the improper folding of the protein and its degradation before it reaches the plasma membrane of epithelial cells. Present correctors, like VX809 only induce a partial rescue of the mutant protein. Our previous studies reported a...

Uploaded on: April 14, 2023