PAGANO , S

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Auto-antibodies to apolipoprotein A-1 (anti-apoA-1 IgG) were shown to promote inflammation and atherogenesis, possibly through innate immune receptors signalling. Here, we aimed at investigating the role of Toll-like receptors (TLR) 2 and 4 on anti-apoA-1 IgG-induced atherosclerotic plaque vulnerability, myocardial necrosis and mortality in...

In vitro and animal studies point to autoantibodies against apolipoproteinA-1 (anti-apoA-1 IgG) as possible mediators of cardiovascular disease involving several mechanisms, such as basal heart rate interference mediated by a mineralocorticoid receptor (MR)-dependent L-type calcium channel activation, and a direct pro-inflammatory effect...

Aims. The activation of cannabinoid receptor type 2 CB(2)-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB(2) pharmacological activation on markers of plaque vulnerability in vivo and in vitro. Methods...