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Last name: PAGNOTTA
First name: Sophie
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Macrophage Migration Inhibitory Factors (MIF) are pivotal cytokines/chemokines for vertebrate immune systems. MIFs are typically soluble single-domain proteins that are conserved across plant, fungal, protist, and metazoan kingdoms, but their functions have not been determined in most phylogenetic groups. Here, we describe an atypical...
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PURPOSE: Changes in extracellular pH occur in the retina and directly affect retinal activity and phototransduction. The authors analyzed the expression in rodent retina of ASIC3, a sensor of extracellular acidosis, and used ASIC3 knockout mice to explore its role in retinal function and survival. METHODS: The expression and the role of ASIC3...
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The reinforcement of poly(hydroxyethyl acrylate) provided by sepiolite particles has been analysed. Stress-strain measurements at equilibrium, as well as swelling experiments, were carried out on the unfilled and filled polymers. The state of dispersion of the filler was characterized by transmission electron microscopy. Moreover, an evaluation...
Polypropylene (PP)-based nanocomposites reinforced with three different organoclays (Dellite© 67 G, Cloisite© 20, and Cloisite© 30B) were prepared via melt-mixing in an internal mixer. The three organoclays differ essentially via their organic modifier and interlamellar distance. The nanocomposites microstructure was characterized at different...
Elastomer filled with fibrous clay (sepiolite) was manufactured using a hydrophilic elastomer matrix, poly 2-hydroxyethylacrylate (PHEA). The surface silanol groups located onto the channel sides of the sepiolite were functionalized with both octyltrimethoxysilane (OTMS) and 3-methacryloxypropyltrimethoxysilane (MPTMS), which form covalent...
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Abstract Cell apical constriction driven by actomyosin contraction forces is a conserved mechanism during tissue folding in embryo development. While much is now understood of the molecular mechanism responsible for apical constriction and of the tissue-scale integration of the ensuing in-plane deformations, it is still not clear if apical...
Cnidarian-dinoflagellate symbiosis disruption and subsequent bleaching are major concerns, especially regarding their ecological consequences on coral reefs and temperate coralligenous communities. Cnidarian bleaching is caused by a variety of environmental stressors, such as elevated seawater temperature associated with global climate change,...
The purpose of this article is to understand the underlying mechanisms of the potential of nanohybrids. Two types of fillers were dispersed in a biocompatible organic matrix, poly-(hydroxyethyl acrylate) (PHEA): either a natural fibrous clay (pristine sepiolite), or a natural nanopigment (Maya Blue). In comparison with the pure polymer, the...
Cnidarian-dinoflagellate symbiosis disruption and subsequent bleaching are major concerns, especially regarding their ecological consequences on coral reefs and temperate coralligenous communities. Cnidarian bleaching is caused by a variety of environmental stressors, such as elevated seawater temperature associated with global climate change,...
Unusual self-organization of sepiolite fibbers have been found during the synthesis of sustainable nanocomposites. These auto-structured networks are synthesized starting with an epoxidized linseed oil (ELO), a bio-based hardener of dicarboxylic class and sepiolite fibbers. For the first time, the auto-organization of sepiolite fibbers into...
Le renforcement des polymères est très souvent réalisé par des nanocharges en raison de leursgrandes surfaces de contact, jouant un rôle particulier sur leurs comportements. Parfois de formesanalogues à celles de fibres, ces charges jouent un rôle important dans les propriétés thermiques,mécaniques, optiques ou barrières et permettent de...
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Ciliogenesis is a coordinated process initiated by the recruitment and fusion of pre-ciliary vesicles at the distal appendages of the mother centriole through mechanisms that remain unclear. Here, we report that EFA6A (also known as PSD), an exchange factor for the small G protein Arf6, is involved in early stage of ciliogenesis by promoting...
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Cancer stem cells (CSCs) represent a minor population of cancer cells with stem cell-like properties which are able to fuel tumor growth and resist conventional treatments. Autophagy has been described to be upregulated in some CSCs and to play a crucial role by maintaining stem features and promoting resistance to both hostile...
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The symbiotic interaction between cnidarians (e.g., corals and sea anemones) and photosynthetic dinoflagellates of the genus Symbiodinium is triggered by both host–symbiont recognition processes and metabolic exchange between the 2 partners. The molecular communication is crucial for homeostatic regulation of the symbiosis, both under normal...