PALMIERI G.

BACKGROUND: Previous studies showed that the subtype 2 of somatostatin receptors (sstr2) is generally expressed by soft tissue sarcomas. MATERIALS AND METHODS: Using reverse transcription-polymerase chain reaction (RT-PCR), the present study evaluated the expression of sstr mRNA in 31 human intermediate and malignant soft tissue tumors. In 8...

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Background: Imatinib mesylate (STI-571, Gleevec) a small molecule tyrosine kinase inhibitor directed against the enzymatic domain of KIT protein, was recently found to produce dramatic clinical responses as monotherapy for metastatic GISTs. However, imatinib resistance can occur determining treatment failure. The present study was performed to...

Cutaneous squamous cell carcinomas (CSCC) account for about 20% of all keratinocyte carcinomas, which are the most common form of cancer. Heterogeneity of treatments and low mortality are a challenge in obtaining accurate incidence data and consistent registration in cancer registries. Indeed, CSCC mostly presents as an indolent, low-risk...