Adenylate kinases (AKs) are ubiquitous monomeric phosphotransferases, which play a pivotal role in the energetic metabolism. At the present, nine isoforms are known. AKs catalyze the following reversible reaction: ATP + AMP ↔ 2 ADP, even though isoform 3 uses GTP instead ATP. For many years, the activity of AKs has been detected only after...
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2017 (v1)PublicationUploaded on: April 14, 2023
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2017 (v1)Publication
In face of innovative therapeutic strategies for cancer diagnosis and treatment, and of the elusiveness of renal and urinary tract tumors, the identification of novel biomarkers for diagnosis, prognosis, selection and monitoring of therapies is a primary target of research. The concept of "precision medicine" for tailoring the oncologic...
Uploaded on: April 14, 2023 -
2016 (v1)Publication
The term Exosome has come into use to define nanovesicles contained in multivesicular endosomes (MVE), secreted by fusion of MVE with the plasma membrane. Exosomes are secreted in vivo by almost any cell type and can be isolated from body fluids. Indeed, circulating vesicles account for both exosomes and microvesicles (MVs), which can be...
Uploaded on: April 14, 2023 -
2020 (v1)Publication
The novel coronavirus infectious disease (COVID-19) has rapidly spread and poses a great challenge to researchers, both in elucidating its pathogenic mechanism and developing effective treatments. It has been recently proposed that COVID-19 is an endothelial disease. Indeed, the COVID-19 virus binds to angiotensin-converting enzyme type 2...
Uploaded on: February 4, 2024 -
2020 (v1)Publication
Exosomes, nanovesicles of endocytic origin, are secreted by most cell types; cancer cells representing no exception. Exosomes facilitate intercellular communication as they deliver diverse proteins, mRNA, miRNA and lipids. In this review, we discuss how exosomes represent one of the main risks associated with cancer but also one of the most...
Uploaded on: April 14, 2023 -
2023 (v1)Publication
: Mitochondria have been the prerequisite to eukaryote complexity since their likely endosymbiotic origin, allowing a remarkable expansion in the number of genes expressed [...].
Uploaded on: February 11, 2024