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PARDIÑAS , Antonio F.

Last name: PARDIÑAS

First name: Antonio F.

June 12, 2023 (v1)

Publication

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Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium

Smart, Sophie E. Agbedjro, Deborah Pardiñas, Antonio F.

Introduction Our aim was to, firstly, identify characteristics at first-episode of psychosis that are associated with later antipsychotic treatment resistance (TR) and, secondly, to develop a parsimonious prediction model for TR. Methods We combined data from ten prospective, first-episode psychosis cohorts from across Europe and categorised...

Uploaded on: June 14, 2023
November 22, 2022 (v1)

Publication

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Interaction testing and polygenic risk scoring to estimate the association of common genetic variants with treatment resistance in schizophrenia

Pardiñas, Antonio F. Smart, Sophie E. Willcocks, Isabella R.

Importance About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known as treatment-resistant schizophrenia (TRS). The causes of treatment resistance and their relationships with causes underlying...

Uploaded on: March 24, 2023