El estrés oxidativo y la producción de especies reactivas de oxígeno (ROS) juegan un papel muy importante en el daño neuronal. Numerosas evidencias apuntan a que contribuyen a la degeneración neuronal que subyace a muchas enfermedades neurodegenerativas, como son la Esclerosis Lateral Amiotrófica (ELA), la enfermedad de Parkinson o la...
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February 5, 2018 (v1)PublicationUploaded on: December 4, 2022
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March 3, 2021 (v1)Publication
Oxidative stress is one of the main proposed mechanisms involved in neuronal degeneration. To evaluate the consequences of oxidative stress on motor cortex pyramidal neurons during postnatal development, rats were classified into three groups: Newborn (P2–P7); infantile (P11–P15); and young adult (P20–P40). Oxidative stress was induced by 10 µM...
Uploaded on: March 26, 2023 -
September 20, 2022 (v1)Publication
Neurodegenerative diseases are characterized by gradually progressive, selective loss of anatomically or physiologically related neuronal systems that produce brain damage from which there is no recovery. Despite the differences in clinical manifestations and neuronal vulnerability, the pathological processes appear to be similar, suggesting...
Uploaded on: December 5, 2022 -
February 7, 2024 (v1)Publication
It has been claimed that oxidative stress and the production of reactive oxygen radicals can contribute to neuron degeneration and might be one factor in the development of different neurological diseases. In our study, we have attempted to clarify how oxidative damage induces dose dependent changes in functional membrane properties of neurons...
Uploaded on: February 11, 2024 -
February 15, 2021 (v1)Publication
Glioblastoma (GBM) is the most common form of brain tumor characterized by its resistance to conventional therapies, including temozolomide, the most widely used chemotherapeutic agent in the treatment of GBM. Within the tumor, the presence of glioma stem cells (GSC) seems to be the reason for drug resistance. The discovery of GSC has boosted...
Uploaded on: March 26, 2023 -
January 26, 2022 (v1)Publication
Achieving the distinctive complex behaviors of adult mammals requires the development of a great variety of specialized neural circuits. Although the development of these circuits begins during the embryonic stage, they remain immature at birth, requiring a postnatal maturation process to achieve these complex tasks. Understanding how the...
Uploaded on: December 4, 2022 -
June 6, 2023 (v1)Publication
Harmonic mechanisms orchestrate neurogenesis in the healthy brain within specific neurogenic niches, which generate neurons from neural stem cells as a homeostatic mechanism. These newly generated neurons integrate into existing neuronal circuits to participate in different brain tasks. Despite the mechanisms that protect the mammalian brain,...
Uploaded on: June 7, 2023