PARDOSSI-PIQUARD , R.

Background: Alzheimer's disease (AD) is associated with extracellular accumulation and aggregation of amyloid β (Aβ) peptides ultimately seeding in senile plaques. Recent data show that their direct precursor C99 (βCTF) also accumulates in AD-affected brain as well as in AD-like mouse models. C99 is consistently detected much earlier than Aβ,...

Mitochondria dysfunctions and mitophagy failure have been associated with several Alzheimer's disease (AD) related molecular actors including amyloid beta (Aβ) and recently the amyloid precursor protein-C terminal fragments (APP-CTFs). The efficacy of the mitophagy process in neurons relies on regulated mitochondrial transport along axons...

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Triple-transgenic mice (3xTgAD) overexpressing Swedish-mutated ␤-amyloid precursor protein (␤APP swe), P310L-Tau (Tau P301L), and physiological levels of M146V-presenilin-1 (PS1 M146V) display extracellular amyloid-␤ peptides (A␤) deposits and Tau tangles. More disputed is the observation that these mice accumulate intraneuronal A␤ that has...