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PARRA-MILLÁN , Raquel

Last name: PARRA-MILLÁN

First name: Raquel

October 6, 2022 (v1)

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AOA-2 Derivatives as Outer Membrane Protein A Inhibitors for Treatment of Gram-Negative Bacilli Infections

Ayerbe Algaba, Rafael Bayó, Nuria Verdú, Ester

Previously, we identified that a cyclic hexapeptide AOA-2 inhibited the interaction of Gram-negative bacilli (GNB) like Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli to host cells thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model. In this work, we aimed to evaluate in...

Uploaded on: March 24, 2023
November 30, 2022 (v1)

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Impact of the immune response modification by lysophosphatidylcholine in the efficacy of antibiotic therapy of experimental models of peritoneal sepsis and pneumonia by Pseudomonas aeruginosa: LPC therapeutic effect in combined therapy

Parra-Millán, Raquel Jiménez-Mejías, Manuel E. Ayerbe-Algaba, Rafael

introducción: La estimulación de la respuesta inmunitaria podría ser adyuvante al tratamiento antimi- crobiano. En este estudio, hemos evaluado el impacto de la modificación de la respuesta inmunitaria por la lisofosfatidilcolina (LPC), combinada con imipenem ó ceftazidima, en modelos murinos de sepsis peritoneal (SP) y de neumonía por...

Uploaded on: December 4, 2022