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PARRINI , Martina

Last name: PARRINI

First name: Martina

2017 (v1)

Publication

Metadata-only

Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

Parrini, Martina Ghezzi, Diego Deidda, Gabriele

Down syndrome (DS) is caused by the triplication of human chromosome 21 and represents the most frequent genetic cause of intellectual disability. The trisomic Ts65Dn mouse model of DS shows synaptic deficits and reproduces the essential cognitive disabilities of the human syndrome. Aerobic exercise improved various neurophysiological...

Uploaded on: April 14, 2023
2024 (v1)

Publication

Metadata-only

Heterogeneous subpopulations of GABAAR-responding neurons coexist across neuronal network scales and developmental stages in health and disease

Colombi, Ilaria Rastogi, Mohit Parrini, Martina

: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in adults. Depolarizing GABA responses have been well characterized at neuronal-population average level during typical neurodevelopment and partially in brain disorders. However, no investigation has specifically assessed whether a mosaicism of cells with either...

Uploaded on: July 3, 2024