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PASCALE , Lise

Last name: PASCALE

First name: Lise

April 19, 2013 (v1)

Journal article

Metadata-only

Thermodynamic studies of a series of homologous HIV-1 TAR RNA ligands reveal that loose binders are stronger Tat competitors than tight ones

Pascale, Lise Azoulay, Stéphane Di Giorgio, Audrey

RNA is a major drug target, but the design of small molecules that modulate RNA function remains a great challenge. In this context, a series of structurally homologous 'polyamide amino acids' (PAA) was studied as HIV-1 trans-activating response (TAR) RNA ligands. An extensive thermodynamic study revealed the occurence of an enthalpy–entropy...

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