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PELLISTRI , Francesca

Last name: PELLISTRI

First name: Francesca

Institution: UNIGE

Links

2017 (v1)

Publication

Metadata-only

Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates and prevent toxicity in neural cells and Caenorhabditis elegans animal model

Visentin, Cristina Pellistri, Francesca Natalello, Antonino

The protein ataxin-3 (ATX3) triggers an amyloid-related neurodegenerative disease when its polyglutamine stretch is expanded beyond a critical threshold. We formerly demonstrated that the polyphenol epigallocatechin-3-gallate (EGCG) could redirect amyloid aggregation of a full-length, expanded ATX3 (ATX3-Q55) towards non-toxic, soluble,...

Uploaded on: April 14, 2023