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PERICO , Angelo

Last name: PERICO

First name: Angelo

2016 (v1)

Publication

Metadata-only

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

GALANTE, DENISE Ruggeri, Francesco Simone Dietler, Giovanni

A wide consensus based on robust experimental evidence indicates pyroglutamylated amyloid-β isoform (AβpE3-42) as one of the most neurotoxic peptides involved in the onset of Alzheimer's disease. Furthermore, AβpE3-42 co-oligomerized with excess of Aβ1-42, produces oligomers and aggregates that are structurally distinct and far more cytotoxic...

Uploaded on: April 14, 2023