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PERSSON , Annette

Last name: PERSSON

First name: Annette

July 7, 2023 (v1)

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Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients

Burguillos García, Miguel Ángel Hajji, Nabil Englund, Elisabet

We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced caspase-3 activation in the rat ventral mesencephalon, which was mostly associated with glial cells. In contrast, nigral DA neurons exhibited AIF nuclear translocation in response to LPS. A significant decrease of the...

Uploaded on: July 8, 2023
February 22, 2017 (v1)

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Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke

Rodhe, Johanna Burguillos García, Miguel Ángel Martínez de Pablos, Rocío

Ischemic stroke (caused by thrombosis, embolism or vasoconstriction) lead to the recruitment and activation of immune cells including resident microglia and infiltrating peripheral macrophages, which contribute to an inflammatory response involved in regulation of the neuronal damage. We showed earlier that upon pro-inflammatory stimuli, the...

Uploaded on: December 4, 2022