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PETTMANN , Brigitte

Last name: PETTMANN

First name: Brigitte

February 5, 2005 (v1)

Journal article

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Expression of a dominant negative form of Daxx in vivo rescues motoneurons from Fas (CD95)-induced cell death.

Raoul, Cedric Barthelemy, Catherine Couzinet, Arnaud

Fas-induced death of motoneurons in vitro has been shown to involve two signaling cascades that act together to execute the death program: a Fas-Daxx-ASK-1-p38 kinase-nNOS branch, which controls transcriptional and post-translational events, and the second classical Fas-FADD-caspase-8 branch. To analyze the role of Daxx in the developmental...

Uploaded on: December 4, 2022
September 17, 2003 (v1)

Journal article

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Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo.

Ugolini, Gabriele Raoul, Cédric Ferri, Anna

Activation of the Fas death receptor leads to the death of motoneurons in culture. To investigate the role of Fas in programmed cell death and pathological situations, we used several mutant mice deficient for Fas signaling and made a novel transgenic FADD-DN (FAS-associated death domain-dominant-negative) strain. In vitro, motoneurons from all...

Uploaded on: December 4, 2022