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PEUCHMAUR , Marine

Last name: PEUCHMAUR

First name: Marine

February 2013 (v1)

Journal article

Metadata-only

Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein

Peuchmaur, Marine Lacour, Marie-Agnès Sévalle, Jean

The 3-alkoxy-7-amino-4-chloro-isocoumarins JLK-6 and JLK-2 have been shown to markedly reduce the production of Amyloid β-peptide (Aβ) by Amyloid-β Precursor Protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor. This suggested that these compounds do not...

Uploaded on: December 3, 2022