PIERZYNSKA-MACH , Agnieszka

The DEK oncoprotein is a ubiquitous nuclear factor that has been consistently associated with tumor progression: its expression level differs between normal and cancer cells, raising the possibility of using DEK as a tumor marker. Moreover, DEK is a non-histone architectural chromatin factor that may influence nucleosomal accessibility and...

Epigenetic dysregulation of chromatin is one of the hallmarks of cancer development and progression, and it is continuously investigated as a potential general bio-marker of this complex disease. One of the nuclear factors involved in gene regulation is the unique DEK protein-a histone chaperon modulating chromatin topology. DEK expression...