PILAT , Dominika

We previously discovered the implication of membrane-type 5-matrix metalloproteinase (MT5-MMP) in Alzheimer's disease AD pathogenesis. Here we shed new light on pathogenic mechanisms by which MT5-MMP controls APP processing and the fate of amyloid beta peptide (Aβ), its precursor C99 and C83. We found in HEK carrying the APP Swedish familial...

Abbreviations: 3xTG, transgenic mice expressing human APP, MAPT, and PSEN1 genes with three familial mutations; 5xFAD, transgenic mice expressing human APP and PSEN1 genes with five familial mutations; AD, Alzheimer's disease; ADAM, a disintegrin and metalloprotease; APP, amyloid protein precursor; Aβ, beta-amyloid peptide; BACE-1, beta-site...