Los iminoazúcares constituyen la categoría más importante de inhibidores de glicosidasas, sin embargo, su escasa selectividad de inhibición y de permeabilidad a través de las membranas biológicas, frecuentemente limitan su utilización a nivel terapéutico. Es por ello que, en la presente Tesis Doctoral hemos abordado la síntesis de nuevos...
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December 2, 2021 (v1)PublicationUploaded on: December 4, 2022
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March 24, 2022 (v1)Publication
Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions from the respective azido/aminohexylpyrrolidine iminosugar precursors. The resulting monomeric and dimeric compounds were screened for inhibition of β-N-acetylglucosaminidase from Jack beans, the plant ortholog of human...
Uploaded on: December 4, 2022 -
January 25, 2019 (v1)Publication
The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in situ biological evaluation toward α -galactosidases has been carried out. The combination of the (thio)urea-forming click reaction and the in situ screening is pioneer in the search for glycosidase inhibitors and has allowed the...
Uploaded on: December 4, 2022