June 26, 2015 (v1)
Publication
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Uploaded on: March 27, 2023
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September 20, 2017 (v1)Publication
Proteostasis alteration and neuroinflammation are typical features of normal aging. We have previously shown that neuroinflammation alters cellular proteostasis through immunoproteasome induction, leading to a transient decrease of proteasome activity. Here, we further investigated the role of acute lipopolysaccharide (LPS)-induced hippocampal...
Uploaded on: March 27, 2023 -
December 5, 2017 (v1)Publication
To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that induction of pro-inflammatory factors as TNF-α and iNOS was directly related to cell density, meanwhile the induction of the...
Uploaded on: December 4, 2022 -
May 24, 2016 (v1)Publication
Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression of several age-related neurodegenerative disorders. However, the mechanisms linking proteasome dysfunction to cell degeneration are poorly understood. We examined in young and aged rat hippocampus the activation of the...
Uploaded on: December 4, 2022 -
March 3, 2015 (v1)Publication
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Uploaded on: March 25, 2023