Fat cell accumulation in skeletal muscle is a major characteristic of various disorders, such as obesity, sarcopenia and dystrophies. Moreover, these fat cells could be involved in muscle homeostasis regulation as previously described for adipocytes in bone marrow. Despite recent advances on the topic, no clearly characterized mouse model is...
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June 4, 2010 (v1)Journal articleUploaded on: December 4, 2022
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November 1, 2020 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
November 10, 2012 (v1)Journal article
Brown adipose tissue (BAT) has long been thought to be absent or very scarce in human adults so that its contribution to energy expenditure was not considered as relevant. The recent discovery of thermogenic BAT in human adults opened the field for innovative strategies to combat overweight/obesity and associated diseases. This...
Uploaded on: December 2, 2022 -
2011 (v1)Journal article
It is well established now that adult humans possess active brown adipose tissue (BAT) which represents a potential pharmacological target to combat obesity and associated diseases. Moreover thermogenic brown-like adipocytes ("brite adipocytes") appear also in mouse white adipose tissue (WAT) upon β3-adrenergic stimulation. We had previously...
Uploaded on: December 3, 2022 -
June 3, 2005 (v1)Journal article
Myodulin is a new integral membrane protein down-regulated in skeletal muscle atrophy. A first characterization suggested that myodulin could be a skeletal muscle angiogenic factor operating through direct cell-to-cell interactions. Here, we show that mouse myodulin can be expressed at the plasma membrane of Saccharomyces cerevisiae and...
Uploaded on: December 4, 2022 -
April 7, 2009 (v1)Journal article
Muscle disorders such as Duchenne muscular dystrophy (DMD) still need effective treatments, and mesenchymal stem cells (MSCs) may constitute an attractive cell therapy alternative because they are multipotent and accessible in adult tissues. We have previously shown that human multipotent adipose-derived stem (hMADS) cells were able to restore...
Uploaded on: December 4, 2022 -
January 1, 2004 (v1)Journal article
We examined the expression and function of a gene we previously cloned from its downregulation in a muscle atrophy model. The encoded protein was named myodulin because of sequence homologies with the cartilage-specific chondromodulin-I (ChM-I) protein, its restricted expression in skeletal muscle tissue, and its modulating properties on...
Uploaded on: December 4, 2022 -
November 30, 2014 (v1)Journal article
The increase of life expectancy has led to the increase of age-related diseases such as osteoporosis. Osteoporosis is characterized by bone weakening promoting the occurrence of fractures with defective bone regeneration. Men aged over 50 have a prevalence for osteoporosis of 20%, which is related to a decline in sex hormones occurring during...
Uploaded on: February 28, 2023 -
October 8, 2010 (v1)Journal article
Skeletal muscle cells constitute a heterogeneous population which maintains muscle integrity through a high myogenic regenerative capacity. More unexpectedly this population is also endowed with an adipogenic potential, even in humans, and intra-muscular adipocytes have been found to be present in several disorders. We tested the distribution...
Uploaded on: December 4, 2022 -
June 16, 2011 (v1)Journal article
Sigma-1 receptor (Sig1R) is a 25-kDa protein structurally unrelated to other mammalian proteins. Sig1R is present in brain, liver, and heart and is overexpressed in cancer cells. Studies using exogenous sigma ligands have shown that Sig1R interact with a variety of ion channels, but its intrinsic function and mechanism of action remain unclear....
Uploaded on: December 4, 2022 -
June 16, 2011 (v1)Journal article
Sigma-1 receptor (Sig1R) is a 25-kDa protein structurally unrelated to other mammalian proteins. Sig1R is present in brain, liver, and heart and is overexpressed in cancer cells. Studies using exogenous sigma ligands have shown that Sig1R interact with a variety of ion channels, but its intrinsic function and mechanism of action remain unclear....
Uploaded on: February 22, 2023 -
June 16, 2011 (v1)Journal article
Sigma-1 receptor (Sig1R) is a 25-kDa protein structurally unrelated to other mammalian proteins. Sig1R is present in brain, liver, and heart and is overexpressed in cancer cells. Studies using exogenous sigma ligands have shown that Sig1R interact with a variety of ion channels, but its intrinsic function and mechanism of action remain unclear....
Uploaded on: December 3, 2022 -
November 10, 2014 (v1)Journal article
Brown adipose tissue is the primary site for thermogenesis and can consume, in addition to free fatty acids, a very high amount of glucose from the blood, which can both acutely and chronically affect glucose homeostasis. Here, we show that mechanistic target of rapamycin (mTOR) complex 2 has a novel role in β3-adrenoceptor-stimulated glucose...
Uploaded on: March 26, 2023