PLONKA , Alexandra

Primary Progressive Aphasia (PPA) is a neurodegenerative syndrome initially characterized by an isolated language disorder and which diagnosis is mainly clinical. Three main PPA subtypes have been described in the literature: logopenic PPA (lvPPA), semantic PPA (svPPA) and non-fluent/agrammatic PPA (nfavPPA). The latest data in the literature...

International audience

International audience

The logopenic variant of Primary Progressive Aphasia (lvPPA), a syndromic disorder centered on language impairment, often presents variable underlying neurodegenerative pathologies such as Alzheimer Disease (AD). Actual language assessment tests and lumbar puncture, focused on AD diagnosis, cannot precisely distinguish the symptoms, or predict...