Pyrimido-pyrimidine derivatives have been developed as rigid merbarone analogues. In a previous study, these compounds showed potent antiproliferative activity and efficiently inhibited topoisomerase IIα. To further extend the structure–activity relationships on pyrimido-pyrimidines, a novel series of analogues was synthesized by a two-step...
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2021 (v1)PublicationUploaded on: April 14, 2023
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2022 (v1)Publication
A series of highly functionalized pyrazole derivatives has been prepared by a one-pot, versatile and regioselective procedure. Pyrazoles 1–29 were tested in cell-based assay to assess their antiproliferative activity against a panel of tumour cells. Additionally, the cytotoxicity of prepared compounds was evaluated against normal human...
Uploaded on: April 14, 2023 -
2024 (v1)Publication
Push-pull alkenes refer to substituted alkenes bearing one or two electron-donating groups at one end of the double bond and one or two electron-accepting groups at the other end. These chemical properties make push-pull alkenes particularly reactive with electrophilic and nucleophilic species and therefore they have been widely used as...
Uploaded on: July 3, 2024 -
2013 (v1)Publication
Sir2-like proteins (Sirtuins) are a class of enzymes conserved throughout the kingdoms of life. In fact, from Archaea to Mammals, these (class III) NAD+-dependent deacetylases catalyse the removal of the acetyl moiety from a substrate protein. Sirtuins show a conserved central catalytic domain with two more variable amino- and carboxy-terminal...
Uploaded on: December 5, 2022