Purpose: Combination antiretroviral therapy (ART) has proven to be effective in treating human immunodeficiency virus (HIV) infection. Chronic administration of antiretrovirals presents significant challenges, including the risk of selecting treatment-resistant viral strains that can determine treatment failure and can be transmitted. In many...
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2008 (v1)PublicationUploaded on: April 14, 2023
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2023 (v1)Publication
Candida auris has become a major concern in critical care medicine due to the increasing number of immunocompromised patients and candidiasis is the most frequent cause of fungal infections. C. auris and other fungal pathogens are responsible for at least 13 million infections and 1.5 million deaths globally per year. In immunocompromised...
Uploaded on: January 31, 2024 -
2021 (v1)Publication
Background. Italy was the first western country to face an uncontrolled outbreak of SARSCoV-2 infection. The epidemic began in March 2020 within a context characterised by a general lack of knowledge about the disease. The first scientific evidence emerged months later, leading to treatment changes. The aim of our study was to evaluate the...
Uploaded on: April 14, 2023 -
2024 (v1)Publication
Background and aims: Ceftobiprole is a recent 5th generation parenteral cephalosporin with antibacterial activity against a large range Gram+ and Gram- bacteria. Therapeutic drug monitoring (TDM) is an essential tool for maintaining plasma concentrations of antibiotics above the MIC by the end of the dosing interval, thus preventing the...
Uploaded on: July 14, 2024 -
2020 (v1)Publication
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Uploaded on: April 14, 2023 -
2024 (v1)Publication
In several settings, the COVID-19 pandemic determined a negative impact on the occurrence of healthcare-associated infection, particularly for on central lines associated bloodstream infections (CLABSI). In our setting, we observed a significant increase in CLABSI in our intensive care unit (ICU) during 2020 and 2021 vs. 2018 to 2019. A...
Uploaded on: February 24, 2024 -
2021 (v1)Publication
Background: IL-1 plays a pivotal role in the inflammatory response during cytokine storm syndromes. Objective: Our aim was to analyze the efficacy and safety of early anti-inflammatory treatment (AIT) with intravenous anakinra with or without glucocorticoids in coronavirus disease 2019 (COVID-19) pneumonia. Methods: We performed a retrospective...
Uploaded on: April 14, 2023 -
2021 (v1)Publication
Background: Anakinra might improve the prognosis of patients with moderate to severe COVID-19 (ie, patients requiring oxygen supplementation but not yet receiving organ support). We aimed to assess the effect of anakinra treatment on mortality in patients admitted to hospital with COVID-19. Methods: For this systematic review and individual...
Uploaded on: April 14, 2023