November 2004 (v1)
Journal article
Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.
Increased expression of vascular endothelial growth factor (VEGF) contributes to the growth of many tumors by increasing angiogenesis. Although hypoxia is a potent inducer of VEGF, we previously showed that epidermal growth factor receptor amplification and loss of PTEN, both of which can increase phosphatidylinositol-3-kinase (PI3K) activity,...
Uploaded on: December 4, 2022