PROVENZANO FRANCESCA

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective death of motoneurons (MNs). ALS is also defined a non-cell-autonomous disease, due to the contribution of glial cells that acquire an aberrant reactive phenotype and secrete neurotoxic factors toward MN. At present there is no effective cure for...

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Amyotrophic lateral sclerosis (ALS) is fatal neurodegenerative disease due to a progressive degeneration of motor neurons (MNs). The aetiology is still largely obscure, and several mechanisms have been proposed, including glutamate (Glu)-mediated excitotoxicity. In this context, group I metabotropic Glu receptors (mGluR1/5) play an active role,...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective death of motoneurons (MNs). Despite significant progress the precise pathological mechanisms of MN death remain largely obscure. ALS is also defined a non-cell-autonomous disease, due to the contribution of glial cells that acquire an...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective death of motoneurons (MNs). Despite significant progress the precise pathological mechanisms of MN death remain largely obscure. ALS is also defined a non-cell-autonomous disease, due to the contribution of glial cells that acquire an...

INTRODUCTION. Amyotrophic lateral sclerosis (ALS) is fatal neurodegenerative disease characterised by a progressive degeneration of motor neurons (MNs). The aetiology is still largely obscure, and several mechanisms have been proposed, including glutamate (Glu)-mediated excitotoxicity. In this context, group I metabotropic Glu receptors...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by upper and lower motor neurons (MNs) death, with an important contribution of glial cells. We previously demonstrated that the intravenous administration of mesenchymal stem cells (MSCs), prolonged survival probability and ameliorated pathological features...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by upper and lower motor neurons (MNs) death, with an important contribution of glial cells. We previously demonstrated that the intravenous administration of mesenchymal stem cells (MSCs), prolonged survival probability and ameliorated pathological features...