The dimorphic fungi Candida albicans is a major human pathogen that causes life-threatening infections for immunocompromised patients. I have investigated C. albicans invasive filamentous growth, in collaboration with physicists, in particular the mechanical forces during this process, and quantitated the effects of these forces on cell...
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September 25, 2020 (v1)PublicationUploaded on: December 3, 2022
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February 2020 (v1)Journal article
As the majority of fungi are nonmotile, polarized growth in response to an external signal enables them to search for nutrients and mating partners, and hence is crucial for survival and proliferation. Although the mechanisms underlying polarization in response to external signals has commonalities with polarization during mitotic division,...
Uploaded on: December 4, 2022 -
February 2020 (v1)Journal article
As the majority of fungi are nonmotile, polarized growth in response to an external signal enables them to search for nutrients and mating partners, and hence is crucial for survival and proliferation. Although the mechanisms underlying polarization in response to external signals has commonalities with polarization during mitotic division,...
Uploaded on: February 22, 2023 -
February 2020 (v1)Journal article
As the majority of fungi are nonmotile, polarized growth in response to an external signal enables them to search for nutrients and mating partners, and hence is crucial for survival and proliferation. Although the mechanisms underlying polarization in response to external signals has commonalities with polarization during mitotic division,...
Uploaded on: December 4, 2022 -
2019 (v1)Journal article
During symmetry breaking, the highly conserved Rho GTPase Cdc42 becomes stabilized at a defined site via an amplification process. However, little is known about how a new polarity site is established in an already asymmetric cell-a critical process in a changing environment. The human fungal pathogen Candida albicans switches from budding to...
Uploaded on: December 4, 2022 -
October 26, 2021 (v1)Journal article
In a number of elongated cells, such as fungal hyphae, a vesicle cluster is observed at the growing tip. This cluster, called a Spitzenkörper, has been suggested to act as a vesicle supply center, yet analysis of its function is challenging, as a majority of components identified thus far are essential for growth. Here, we probe the function of...
Uploaded on: December 4, 2022 -
2021 (v1)Journal article
Budding yeast cells interpret shallow pheromone gradients from cells of the opposite mating type, polarize their growth toward the pheromone source, and fuse at the chemotropic growth site. We previously proposed a deterministic, gradient-sensing model that explains how yeast cells switch from the intrinsically positioned default polarity site...
Uploaded on: December 3, 2022 -
September 11, 2020 (v1)Journal article
Background: The initial step of a number of human or plant fungal infections requires active penetration of host tissue. For example, active penetration of intestinal epithelia by Candida albicans is critical for dissemination from the gut into the bloodstream. However, little is known about how this fungal pathogen copes with resistive forces...
Uploaded on: February 22, 2023 -
March 25, 2019 (v1)Conference paper
National audience
Uploaded on: December 4, 2022 -
December 2020 (v1)Journal article
International audience
Uploaded on: December 4, 2022