ObjectivesThe aim of our study was to assess the quality of antibiotic prescriptions in a sample of general practitioners (GPs) receiving junior doctors in training, whatever the motive of the prescription.MethodsWe performed a prospective observational study of all antibiotics prescribed in October 2012 by 21 GPs working in southeastern...
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March 2015 (v1)Journal articleUploaded on: December 4, 2022
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2013 (v1)Journal article
Our objectives for this investigation were: (i) to design quality measures of outpatient antibiotic use that could be calculated at the individual general practitioner (GP) level using reimbursement data only; and (ii) to analyse the variability in antibiotic prescriptions between GPs regarding these measures in south-eastern France. Based on...
Uploaded on: March 2, 2023 -
2013 (v1)Journal article
The purpose of this investigation was to adapt to an individual physician level and to the paediatric context a set of drug-specific indicators of outpatient antibiotic use developed by the European Surveillance of Antimicrobial Consumption (ESAC) project, and to describe the differences in antibiotic prescriptions between general practitioners...
Uploaded on: March 2, 2023 -
February 26, 2013 (v1)Journal article
As a result of sub-optimal immunization levels, measles has re-emerged in the EU since 2008 (30 567 cases in 2011), and nearly half of the cases reported are in France. Our objectives were to assess knowledge, attitudes, beliefs and practices of French general practitioners (GPs) towards measles and measles-mumps-rubella (MMR) vaccination. In...
Uploaded on: December 4, 2022 -
2013 (v1)Journal article
Our objectives were to describe the vaccine coverage (VC1) for some occupational vaccines (hepatitis B, pertussis, seasonal and pandemic influenza) among French General Practitioners (GPs2) and to study the factors associated with being vaccinated for each of these four diseases. We surveyed a representative national sample of 1431...
Uploaded on: March 26, 2023 -
2013 (v1)Journal article
Quality indicators assessing the use of antibiotics among general practitioners (GPs) would be useful to target antibiotic stewardship interventions. We adapted to an individual GP level a set of 12 drug-specific quality indicators of outpatient antibiotic use in Europe developed by the European surveillance of antimicrobial consumption...
Uploaded on: February 28, 2023 -
2014 (v1)Journal article
In this investigation, we wanted: (i) to describe the attitudes and declared practices of a representative sample of French general practitioners (GPs) regarding rapid antigen diagnostic tests (RADTs) for acute pharyngitis and (ii) to identify the GPs' characteristics associated with the use of an RADT in the last paediatric patient with...
Uploaded on: March 1, 2023 -
2013 (v1)Journal article
OBJECTIVES: We tested the following hypotheses: (1) risk-averse general practitioners (GPs) might use more Rapid Antigen Diagnostic Tests (RADTs) in tonsillitis in children, probably to decrease their diagnostic uncertainty regarding the aetiology of the disease (viral vs due to group A Streptococcus); and (2) GPs not using RADT might prescribe...
Uploaded on: February 22, 2023 -
February 11, 2011 (v1)Journal article
Staphylococcus aureus, a major causative agent of human infection, produces a large array of virulence factors, including various toxins. Among them, the host RhoA GTPase ADP-ribosylating EDIN toxins are considered as potential virulence factors. Using the polymerase chain reaction (PCR) assay, we analyzed the virulence profile of 256 isolates...
Uploaded on: December 4, 2022 -
June 2013 (v1)Journal article
En France, la couverture vaccinale est insuffisante. Les médecins généralistes étant des acteurs essentiels de la politique vaccinale, il est utile de connaître leurs opinions et pratiques à ce sujet. Nous avons interrogé 1431 médecins généralistes français et 98% se déclaraient favorables à la vaccination dans leur pratique quotidienne. Leurs...
Uploaded on: December 2, 2022 -
2014 (v1)Journal article
Objectives: Urinary tract infections (UTIs) are one of the leading reasons for antibiotic prescriptions in emergency departments (EDs), with half of these antibiotics being inappropriately prescribed. Our objective was to assess the impact of a computerized decision support system (CDSS) on compliance with guidelines on empirical antibiotic...
Uploaded on: March 26, 2023 -
2014 (v1)Journal article
Data on validity of self-reported vaccinations are scarce. This study, performed on healthcare students in Paris (France), aimed to evaluate this validity for occupational vaccinations. The validity of self-reported vaccination status was compared with written information. A total of 432 students were enrolled. Sensitivity rates for BCG,...
Uploaded on: March 26, 2023 -
December 2017 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
June 6, 2018 (v1)Conference paper
International audience
Uploaded on: December 4, 2022 -
April 22, 2017 (v1)Conference paper
International audience
Uploaded on: December 4, 2022 -
2006 (v1)Journal article
The GTPase RhoA is a major regulator of the assembly of actin stress fibers and the contractility of the actomyosin cytoskeleton. The epidermal cell differentiation inhibitor (EDIN) and EDIN-like ADP-ribosyltransferases of Staphylococcus aureus catalyze the inactivation of RhoA, producing actin cable disruption. We report that purified...
Uploaded on: December 2, 2022 -
2006 (v1)Journal article
The GTPase RhoA is a major regulator of the assembly of actin stress fibers and the contractility of the actomyosin cytoskeleton. The epidermal cell differentiation inhibitor (EDIN) and EDIN-like ADP-ribosyltransferases of Staphylococcus aureus catalyze the inactivation of RhoA, producing actin cable disruption. We report that purified...
Uploaded on: October 11, 2023