Q

C

QUARLES , Chad C.

Last name: QUARLES

First name: Chad C.

June 8, 2022 (v1)

Publication

Metadata-only

Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors

Hajji, Nabil García Revilla, Juan Sarmiento Soto, Manuel

New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the arginine-depleting agent ADI-PEG20 in a non-arginine-auxotrophic cellular background (argininosuccinate synthetase 1 positive)....

Uploaded on: December 4, 2022